Generic Name: Lactulose

Brand Name: Accellac

Strength: 3.35g / 5mL

Form: Syrup

Manufacturer: Opal Laboratories (Pvt.) Ltd.

Imported and Distributed by: AccessPoint Interntional Inc.

Classification: Laxatives, Purgatives

Indication/Uses: Lactulose is a synthetic disaccharide osmotic laxative used in the treatment of constipation and in hepatic encephalopathy. Lactulose is broken down by colonic bacteria mainly into lactic acid. This exerts a local osmotic effect in the colon resulting in increased faecal bulk and stimulation of peristalsis. It may take up to 48 hours before an effect is obtained. When larger doses are given for hepatic encephalopathy the pH in the colon is reduced significantly and the absorption of ammonium ions and othes toxic nitrogenous compounds is decreased, leading to a fall in blood-ammonia concentration and an improvement in mental function.